Rejuran Healer, Eye, and HB: What Actually Sets Them Apart

Most people come in having searched "Rejuran" and walk out slightly confused. The clinic menu shows Healer, Eye (i), HB, sometimes S. Each has a different name and a slightly different pitch. If you're not sure which one applies to you, that's understandable.

The short answer: Rejuran is a family of injections, not a single product. All of them carry PN (polynucleotide), the long-chain DNA fragment derived from salmon sperm cells. That regenerative core is shared across every product in the line. What separates Healer from Eye from HB is the PN concentration, whether hyaluronic acid (HA) and lidocaine are added, and which area on the face each formulation is calibrated for. Below is a breakdown of each type by ingredient and concentration, a comparison table, and an honest look at embossing technique and downtime.

Rejuran Is a Family, Not a Single Product

Rejuran is a registered brand from PharmaResearch, a South Korean manufacturer. The active ingredient common to every product in the line is PN (polynucleotide), a long-chain DNA fragment extracted from salmon or trout sperm cells. You'll sometimes see the related term PDRN (polydeoxyribonucleotide) used interchangeably in clinic materials. They come from the same biological source, but PDRN refers to shorter fragments while PN describes longer-chain variants. Rejuran products use PN.

Inside the skin, PN does two things. It provides a moisture-retaining scaffold in the dermis, and it activates fibroblasts to produce collagen and stimulate new microvasculature. That second function is why results emerge gradually over weeks rather than immediately after injection. This is not a filler. It doesn't add volume on contact. Instead, it prompts your skin to rebuild its own structure, which is why a course of three to four sessions spaced a few weeks apart tends to produce more meaningful results than a single treatment.

Every product in the Rejuran family shares that regenerative mechanism. The differences between Healer, Eye (i), HB, and the scar-targeting S come down to where the formula is intended to be used, how concentrated the PN is, and what else has been added to the base. The product names reflect those adjustments, not fundamentally different ingredients.

How the Three Main Types Differ

The three most commonly compared formulations side by side:

Item	Rejuran Healer	Rejuran i (Eye)	Rejuran HB
Manufacturer	PharmaResearch	PharmaResearch	PharmaResearch
Key ingredient	PN (polynucleotide) only	PN (polynucleotide) only	PN + HA (hyaluronic acid) + lidocaine
PN concentration	Highest (approx. 2%)	Lower (approx. 1%)	Lower than Healer (HA compensates)
Formulation viscosity	Standard	Reduced for the periorbital area	HA added for moisture reinforcement
Primary treatment area	Face overall	Eye corners, under-eye	Face overall
Target effect	Skin texture and elasticity regeneration	Fine lines and dullness under the eyes	Regeneration plus immediate hydration and radiance
Injection discomfort	Topical anesthetic required	Topical anesthetic required	Lidocaine included, tends to be less uncomfortable
Embossing (emboss)	Small papules right after injection, settle in 1 to 2 days	More noticeable around the thin eye area	HA extends visible fullness slightly longer

These three are not competing products. They're members of the same family. Rejuran i lowers PN concentration and viscosity to suit the thin, sensitive periorbital skin. Rejuran HB adds HA to layer hydration and immediate radiance alongside the regenerative effect, and includes lidocaine to reduce discomfort during the session. None is categorically superior. The choice follows your concern: overall texture and firmness, the under-eye area specifically, or regeneration combined with instant moisture.

PN and HA: What the Ingredient Difference Means

Two variables separate the formulations on the ingredient level: how concentrated the PN is, and whether HA is present.

Healer carries the highest PN load, around 2%. Eye (i) brings that down to roughly 1%, with viscosity also reduced so the formula spreads easily in the thinner periorbital tissue. HB reduces PN concentration below Healer's level and adds HA to compensate. Healer and Eye are pure-PN formulas, focused entirely on regeneration. HB splits its intent between regeneration and hydration.

Worth noting: PharmaResearch does not publicly disclose precise PN concentrations, so figures across different sources vary slightly. Trust the relative order rather than the exact percentages. Healer is the most concentrated, Eye and HB are lower.

The HA in HB behaves differently from what you'd find in a volumizing filler like Juvederm or Restylane. It's not there to fill hollows or restore lost volume. It's there to hold moisture and deliver an immediate hydrated, radiant appearance while the PN does its slower regenerative work. Think of the PN as the crew rebuilding the structural framework over weeks, and the HA as the humidifier running in the background while the work is in progress. Results from HB's hydration component appear faster after injection than the regenerative changes from the PN.

The lidocaine in HB is a practical addition. Embossing injections, where small droplets are deposited in the superficial dermis at dozens of points across the face, can be uncomfortable even with topical anesthetic. Lidocaine in the formula reduces that discomfort during the session.

One honest caveat: head-to-head clinical trials directly comparing Healer, Eye, and HB for regenerative outcomes are limited. All three share the same PN mechanism, so the regenerative trajectory is similar in principle. Ranking them precisely by efficacy isn't well-supported by current published data.

Embossing Technique and What to Expect After

The question patients ask most often before their first session is about the lumps.

Rejuran is typically injected using a technique called embossing (called 엠보 in Korean clinic settings, embossing in English). The practitioner deposits small individual droplets of the formula just beneath the skin surface at many closely spaced points across the treatment area. Each droplet raises a small visible papule at the injection site, leaving a temporarily bumpy texture across the skin.

This is normal and expected, not a reaction or complication. The papules reflect the product sitting in the superficial dermis as your tissue begins to absorb it. They typically flatten within one to two days. With HB, the added HA retains water in those droplets, so the fullness can take a day or two longer to fully settle compared to Healer.

Bruising is possible with any injection, and the periorbital area is particularly prone to it. The skin under and around the eyes is the thinnest on the face and runs over a dense capillary network. Rejuran Eye (i) patients see bruising more often and more visibly than those receiving Healer to the cheeks or forehead. If you have an event or obligation where visible bruising would be a problem, schedule your session at least a week before it.

A typical session involves dozens to over a hundred injection points distributed evenly across the treatment zone, administered after topical anesthetic. Total session time is usually around thirty to forty minutes. The embossing papules are visible and palpable after, but most patients can go about their day.

For the first day after treatment: skip saunas, alcohol, and intense exercise. All can prolong swelling or worsen bruising. Simple gentle moisturizer and sun protection are the most useful things while the skin settles. While papules remain, thick makeup applied over them causes more irritation than leaving the skin alone.

Which Type Fits Which Concern

The practical guide:

If your main concern is overall skin texture, elasticity, and a loss of that dense, resilient quality across the face, Healer is the baseline choice. It carries the highest PN concentration and focuses entirely on regeneration.

If the under-eye area is the priority, whether thin crepey skin, fine lines, or a dull or dark tone from vascular pooling in thin periorbital tissue, Eye (i) is calibrated for that zone. Its lower viscosity and reduced concentration make it appropriate for skin that Healer's standard formula would be too firm for.

If you want regeneration but also want immediate visible hydration and radiance, and you'd prefer a more comfortable injection, HB covers both. The HA delivers perceptible moisture from the session itself, while the PN gets to work on longer-term repair underneath.

When two concerns overlap, practitioners sometimes split formulations across zones in the same session: Healer across the face and Eye (i) around the periorbital area on the same visit. That's a clinical judgment call based on your specific skin condition and the volume being placed.

A few standard contraindications apply across all Rejuran products. Anyone with a fish allergy must disclose it before a session. The source material is salmon, and while hypersensitivity reactions are uncommon, they can occur. Rejuran is not appropriate during pregnancy, during active infection at the treatment site, or over areas with active inflammation. Patients on anticoagulants or who bruise easily should mention it ahead of time.

The most useful reframe for choosing between types: start with your concern rather than the product name. Is the issue overall skin quality, the eye area specifically, or baseline dryness combined with regeneration? That narrows the field. The exact formulation and session plan are worth working through with your practitioner based on your skin condition and what you're actually hoping to achieve.